There's a lot of flexibility with a system like this, and they even demonstrated decent executions of the concept with things like mino-cum addiction. Corruption and forced transformation are also a better narrative frameworks to hang a game and story around as there are win/lose/win** states baked into things and track with player progression.
'Hold onto your humanity as long as you can ohhhh nooo I've been turned into a depraved demon/furry/futa abomination' is fundamentally more interesting than the gameworlds of TiTs/CoC where all these things are cosmetic surgery that have little fundamental significance to the game experience. Transformations are now essentially a cosmetic you apply to yourself on purpose. TiTS has much less of that, and CoC2 has even less. A big part of what made the first game fun was the forced transformations and corruption, and the fact that transformations were gradual and happened over time.
